GENETIC PREDICTORS OF SEVERE COMPLICATED INFLUENZA A(H1 N1) IN PREGNANT WOMEN

• Main Authors: D. A. Tarbaeva, T. E. Belokrinitskaya
• Format: Article
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2015-09-01
• Series: Acta Biomedica Scientifica
• Subjects: hla; gene polymorphism; hemostasis; hla drb1; severe influenza a(h1n1) pdm2009; pregnancy
• Online Access: https://www.actabiomedica.ru/jour/article/view/124

Polymorphisms of gene-candidates of hemostasis disorder (F2:20210 G>A, F5:1691 G>A, F7:10976 G>A, F13:103 G>T, FGB:455 G>A, ITGA2:807 C>T, ITGB3:1565 T>C, PAI-1:675 5G>4G) and frequency of 14 groups of alleles of the HLA-DRB1 locus were study in women, suffered from flu А(H1N1)pdm09 during pregnancy. Significant association between heterozygotes genotype F7: 0976G/A and complicated forms of influenza was found (OR = 1,5). Mutant homozygotes with PAI-1:675 4G/4G genotype also had high risk of severe complicated influenza A(H1N1) (OR = 1,5). Genotypes HLA DRB1*07*15 and DRB1*16*16 were associated with complicated influenza. We assume, that сombined F7:0976GA, PAI-1:6754G4G and HLA DRB1*07*15, *16*16, DRB1*01*01 genotypes may be genetic predictor of severe complicated flu А(H1N1)pdm09 in pregnancy.