Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module

A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotra...

Full description

Bibliographic Details
Main Authors:	Kilian Krzysztof, Pękal Anna, Juszczyk Julia
Format:	Article
Language:	English
Published:	Sciendo 2016-03-01
Series:	Nukleonika
Subjects:	11c-methionine 11c-radiopharmaceuticals gas phase iodination
Online Access:	https://doi.org/10.1515/nuka-2016-0007

id	doaj-d31de79edb3c424bb8b0bab1f90d4449
record_format	Article
spelling	doaj-d31de79edb3c424bb8b0bab1f90d44492021-09-06T19:21:14ZengSciendoNukleonika0029-59222016-03-01611293310.1515/nuka-2016-0007nuka-2016-0007Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis moduleKilian Krzysztof0Pękal Anna1Juszczyk Julia2Heavy Ion Laboratory, University of Warsaw, 5a Pasteura Str., 02-093 Warsaw, Poland, Tel.: +48 22 554 6214Heavy Ion Laboratory, University of Warsaw, 5a Pasteura Str., 02-093 Warsaw, Poland, Tel.: +48 22 554 6214Faculty of Physics, University of Warsaw, 69 Hoża Str., 02-093 Warsaw, PolandA method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The final product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies.https://doi.org/10.1515/nuka-2016-000711c-methionine11c-radiopharmaceuticalsgas phase iodination
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kilian Krzysztof Pękal Anna Juszczyk Julia
spellingShingle	Kilian Krzysztof Pękal Anna Juszczyk Julia Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module Nukleonika 11c-methionine 11c-radiopharmaceuticals gas phase iodination
author_facet	Kilian Krzysztof Pękal Anna Juszczyk Julia
author_sort	Kilian Krzysztof
title	Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
title_short	Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
title_full	Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
title_fullStr	Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
title_full_unstemmed	Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module
title_sort	synthesis of 11c-methionine through gas phase iodination using synthra meiplus synthesis module
publisher	Sciendo
series	Nukleonika
issn	0029-5922
publishDate	2016-03-01
description	A method of 11C-methionine synthesis using ‘bubbling’ method is presented. 11C-methionine was synthesized via 11C methylation from L-cysteine thiolactone (2 mg) in a 300 μL solution of 2:1:1 (v/v) 1 M NaOH, ethanol, and water at ambient temperature (85°C, 5 min). The radiochemical purity of radiotracer was higher than 99% and enantiomeric purity (L-11C-methionine) was 91.6 ± 0.4%. The final product met the requirements of European Pharmacopoeia monograph. The proposed 11C-methionine synthesis is a reliable tool for routine manufacturing in clinical applications and animal studies.
topic	11c-methionine 11c-radiopharmaceuticals gas phase iodination
url	https://doi.org/10.1515/nuka-2016-0007
work_keys_str_mv	AT kiliankrzysztof synthesisof11cmethioninethroughgasphaseiodinationusingsynthrameiplussynthesismodule AT pekalanna synthesisof11cmethioninethroughgasphaseiodinationusingsynthrameiplussynthesismodule AT juszczykjulia synthesisof11cmethioninethroughgasphaseiodinationusingsynthrameiplussynthesismodule
_version_	1717774838064480256

Synthesis of 11C-methionine through gas phase iodination using Synthra MeIPlus synthesis module

Similar Items