Polyphosphate in Neonates: Less Shedding from Platelets and Divergent Prothrombotic Capacity Due to Lower TFPI Levels

Polyphosphate in Neonates: Less Shedding from Platelets and Divergent Prothrombotic Capacity Due to Lower TFPI Levels

Background: The neonatal hemostatic system exhibits a fragile balance featuring lower levels of clotting factors as well as inhibitors. Neonatal platelets show in-vitro hypoaggregability, but neonates exhibit well-functioning primary and secondary hemostasis despite this impairment. Recently, polyph...

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Bibliographic Details
Main Authors: Axel Schlagenhauf, Harald Haidl, Sina Pohl, Eva-Christine Weiss, Bettina Leschnik, Siegfried Gallistl, Wolfgang Muntean
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Physiology
Subjects:
newborn
polyphosphate
blood platelets
thrombin
blood coagulation tests
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00586/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00586/full

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