TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells

In human uveal melanoma (UM), tumor enlargement is associated with increases in aqueous humor vascular endothelial growth factor-A (VEGF-A) content that induce neovascularization. 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts T...

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Bibliographic Details
Main Authors: Lia Walcher, Clara Budde, Arina Böhm, Peter S. Reinach, Priyavathi Dhandapani, Nina Ljubojevic, Markus W. Schweiger, Henriette von der Waydbrink, Ilka Reimers, Josef Köhrle, Stefan Mergler
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
uveal melanoma
3-iodothyronamine
vascular endothelial growth factor
Intracellular Ca2+
transient receptor potential vanilloid 1 channel
transient receptor potential melastatin 8
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01234/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.01234/full

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