Decreased AMP‐activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury

Decreased AMP‐activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury

Abstract We investigated the hypothesis that exposure of lungs at the saccular stage of development to hyperoxia leads to persistent growth arrest and dysfunction of 5’AMP‐activated protein kinase (AMPK), a key energy sensor in the cell. We exposed neonatal rat pups from postnatal day 1‐ day 10 (P1–...

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Bibliographic Details
Main Authors: Abha Yadav, Ujala Rana, Teresa Michalkiewicz, Ru‐Jeng Teng, Girija G. Konduri
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Physiological Reports
Subjects:
AMP kinase
angiogenesis
bronchopulmonary dysplasia
prematurity
Online Access:https://doi.org/10.14814/phy2.14587

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