In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds

Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diver...

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Main Authors: Eline K. M. Lebbe, Jan Tytgat
Format: Article
Language:English
Published: SciELO 2016-12-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203&lng=en&tlng=en
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spelling doaj-d2f429edcc9d4a21b7a82303b9c130f02020-11-25T01:29:47ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992016-12-0122010.1186/s40409-016-0083-6S1678-91992016000100203In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compoundsEline K. M. LebbeJan TytgatAbstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203&lng=en&tlng=enCone snailConopressinContryphanConantokinContulakinConorfamidConophanConomapConomarphinConolysinConoGAYConoCAPCono-NPY
collection DOAJ
language English
format Article
sources DOAJ
author Eline K. M. Lebbe
Jan Tytgat
spellingShingle Eline K. M. Lebbe
Jan Tytgat
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
Journal of Venomous Animals and Toxins including Tropical Diseases
Cone snail
Conopressin
Contryphan
Conantokin
Contulakin
Conorfamid
Conophan
Conomap
Conomarphin
Conolysin
ConoGAY
ConoCAP
Cono-NPY
author_facet Eline K. M. Lebbe
Jan Tytgat
author_sort Eline K. M. Lebbe
title In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
title_short In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
title_full In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
title_fullStr In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
title_full_unstemmed In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
title_sort in the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
publisher SciELO
series Journal of Venomous Animals and Toxins including Tropical Diseases
issn 1678-9199
publishDate 2016-12-01
description Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs.
topic Cone snail
Conopressin
Contryphan
Conantokin
Contulakin
Conorfamid
Conophan
Conomap
Conomarphin
Conolysin
ConoGAY
ConoCAP
Cono-NPY
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203&lng=en&tlng=en
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