Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

Currently we screened 9 newer synthesized fluoroquinolone derivatives 5(a–i) against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Selected compounds were confirmed by mass...

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Main Authors: Kapil M. Agrawal, Gokul S. Talele
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/147565
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spelling doaj-d2dd03fd026a434c98d96e0a024554892020-11-24T21:33:23ZengHindawi LimitedJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/147565147565Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone DerivativesKapil M. Agrawal0Gokul S. Talele1Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur, Dhule District, Shirpvr 425405, IndiaDepartment of Pharmaceutical Chemistry, Nashik Gramin Shikshan Prasarak Mandal's College of Pharmacy, Triambak Road, Anjaneri, Nashik 422213, IndiaCurrently we screened 9 newer synthesized fluoroquinolone derivatives 5(a–i) against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Selected compounds were confirmed by mass spectral study. Compounds 5(b–d) showed comparable biological activities and other analogues of the series showed moderate-to-weak activity, as compared to the reference marketed drugs.http://dx.doi.org/10.1155/2013/147565
collection DOAJ
language English
format Article
sources DOAJ
author Kapil M. Agrawal
Gokul S. Talele
spellingShingle Kapil M. Agrawal
Gokul S. Talele
Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives
Journal of Chemistry
author_facet Kapil M. Agrawal
Gokul S. Talele
author_sort Kapil M. Agrawal
title Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives
title_short Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives
title_full Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives
title_fullStr Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives
title_full_unstemmed Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives
title_sort synthesis and antibacterial, antimycobacterial activity of 7-[4-{5-(2-oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] quinolone derivatives
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2013-01-01
description Currently we screened 9 newer synthesized fluoroquinolone derivatives 5(a–i) against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Selected compounds were confirmed by mass spectral study. Compounds 5(b–d) showed comparable biological activities and other analogues of the series showed moderate-to-weak activity, as compared to the reference marketed drugs.
url http://dx.doi.org/10.1155/2013/147565
work_keys_str_mv AT kapilmagrawal synthesisandantibacterialantimycobacterialactivityof7452oxo2psubstitutedphenylethylthio134thiadiazol2yl3methylpiperazinylquinolonederivatives
AT gokulstalele synthesisandantibacterialantimycobacterialactivityof7452oxo2psubstitutedphenylethylthio134thiadiazol2yl3methylpiperazinylquinolonederivatives
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