Partial reduction of microglia does not affect tau pathology in aged mice

Abstract Background Activation of inflammation pathways in the brain occurs in Alzheimer’s disease and may contribute to the accumulation and spread of pathological proteins including tau. The goal of this study was to identify how changes in microglia, a key inflammatory cell type, may contribute t...

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Bibliographic Details
Main Authors: Rachel E. Bennett, Annie Bryant, Miwei Hu, Ashley B. Robbins, Sarah C. Hopp, Bradley T. Hyman
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Neuroinflammation
Subjects:
Tau
Online Access:http://link.springer.com/article/10.1186/s12974-018-1348-5