Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study

Yan Zheng,1,* Yin Li,1,2,* Wenqun Xing,1,* Jianjun Qin,1,2 Xianben Liu,1 Ruixiang Zhang,1 Haibo Sun,1 Xiankai Chen1,2 1Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People’s Republic of China; 2Depart...

Full description

Bibliographic Details
Main Authors: Zheng Y, Li Y, Xing W, Qin J, Liu X, Zhang R, Sun H, Chen X
Format: Article
Language:English
Published: Dove Medical Press 2019-10-01
Series:Cancer Management and Research
Subjects:
Online Access:https://www.dovepress.com/serum-fibrinogen-is-an-independent-prognostic-factor-in-operable-esoph-peer-reviewed-article-CMAR
id doaj-d2c26d1c3106425f8ccca2e8e71a6edd
record_format Article
spelling doaj-d2c26d1c3106425f8ccca2e8e71a6edd2020-11-25T02:49:59ZengDove Medical PressCancer Management and Research1179-13222019-10-01Volume 118877888349069Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World StudyZheng YLi YXing WQin JLiu XZhang RSun HChen XYan Zheng,1,* Yin Li,1,2,* Wenqun Xing,1,* Jianjun Qin,1,2 Xianben Liu,1 Ruixiang Zhang,1 Haibo Sun,1 Xiankai Chen1,2 1Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People’s Republic of China; 2Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin LiThe Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, 127# Dongming Road, Zhengzhou 450000, People’s Republic of ChinaTel +86 371 65587226Email liyin0825@hotmail.comPurpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma.Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested.Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043–2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p<0.001) or alcohol consumption (p<0.001), pathological N0 stage (P=0.002), and early pathological TNM stage (I-II) (P=0.004).Conclusion: This research showed that preoperative serum fibrinogen is an independent prognostic factor for survival in ESCC, especially for the early pathological TNM stage (I-II) and N0 patients.Keywords: esophageal cancer, serum fibrinogen, prognostic factor, retrospective study, real world studyhttps://www.dovepress.com/serum-fibrinogen-is-an-independent-prognostic-factor-in-operable-esoph-peer-reviewed-article-CMAResophageal cancerserum fibrinogenprognostic factorretrospective studyreal world study
collection DOAJ
language English
format Article
sources DOAJ
author Zheng Y
Li Y
Xing W
Qin J
Liu X
Zhang R
Sun H
Chen X
spellingShingle Zheng Y
Li Y
Xing W
Qin J
Liu X
Zhang R
Sun H
Chen X
Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
Cancer Management and Research
esophageal cancer
serum fibrinogen
prognostic factor
retrospective study
real world study
author_facet Zheng Y
Li Y
Xing W
Qin J
Liu X
Zhang R
Sun H
Chen X
author_sort Zheng Y
title Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
title_short Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
title_full Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
title_fullStr Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
title_full_unstemmed Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
title_sort serum fibrinogen is an independent prognostic factor in operable esophageal squamous carcinoma: a real-world study
publisher Dove Medical Press
series Cancer Management and Research
issn 1179-1322
publishDate 2019-10-01
description Yan Zheng,1,* Yin Li,1,2,* Wenqun Xing,1,* Jianjun Qin,1,2 Xianben Liu,1 Ruixiang Zhang,1 Haibo Sun,1 Xiankai Chen1,2 1Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People’s Republic of China; 2Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin LiThe Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, 127# Dongming Road, Zhengzhou 450000, People’s Republic of ChinaTel +86 371 65587226Email liyin0825@hotmail.comPurpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma.Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested.Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043–2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p<0.001) or alcohol consumption (p<0.001), pathological N0 stage (P=0.002), and early pathological TNM stage (I-II) (P=0.004).Conclusion: This research showed that preoperative serum fibrinogen is an independent prognostic factor for survival in ESCC, especially for the early pathological TNM stage (I-II) and N0 patients.Keywords: esophageal cancer, serum fibrinogen, prognostic factor, retrospective study, real world study
topic esophageal cancer
serum fibrinogen
prognostic factor
retrospective study
real world study
url https://www.dovepress.com/serum-fibrinogen-is-an-independent-prognostic-factor-in-operable-esoph-peer-reviewed-article-CMAR
work_keys_str_mv AT zhengy serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT liy serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT xingw serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT qinj serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT liux serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT zhangr serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT sunh serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
AT chenx serumfibrinogenisanindependentprognosticfactorinoperableesophagealsquamouscarcinomaarealworldstudy
_version_ 1724740948810792960