The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies

The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies

Besides d-serine, another d-amino acid with endogenous occurrence in the mammalian brain, d-aspartate, has been recently shown to influence NMDA receptor (NMDAR)-mediated transmission. d-aspartate is present in the brain at extracellular level in nanomolar concentrations, binds to the agonist site o...

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Bibliographic Details
Main Authors: Francesco Errico, Tommaso Nuzzo, Massimo Carella, Alessandro Bertolino, Alessandro Usiello
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Psychiatry
Subjects:
d-aspartate
d-serine
schizophrenia
NMDA receptor
d-aspartate oxidase
mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00559/full

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