Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12154 |