New Challenges in Tumor Mutation Heterogeneity in Advanced Ovarian Cancer by a Targeted Next-Generation Sequencing (NGS) Approach

New Challenges in Tumor Mutation Heterogeneity in Advanced Ovarian Cancer by a Targeted Next-Generation Sequencing (NGS) Approach

Next-generation sequencing (NGS) technology has advanced knowledge of the genomic landscape of ovarian cancer, leading to an innovative molecular classification of the disease. However, patient survival and response to platinum-based treatments are still not predictable based on the tumor genetic pr...

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Bibliographic Details
Main Authors: Marica Garziera, Rossana Roncato, Marcella Montico, Elena De Mattia, Sara Gagno, Elena Poletto, Simona Scalone, Vincenzo Canzonieri, Giorgio Giorda, Roberto Sorio, Erika Cecchin, Giuseppe Toffoli
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
advanced ovarian cancer
HGSOC
NGS
tumor profile
concurrent somatic mutations
<i>TP53</i>
platinum sensitivity
driver actionable genes
translational medicine
Online Access:https://www.mdpi.com/2073-4409/8/6/584

Internet

https://www.mdpi.com/2073-4409/8/6/584

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