Loss of WISP2/CCN5 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.

Loss of WISP2/CCN5 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.

It has been proposed that the epithelial-mesenchymal transition (EMT) in mammary epithelial cells and breast cancer cells generates stem cell features. WISP2 (Wnt-1-induced signaling protein-2) plays an important role in maintenance of the differentiated phenotype of estrogen receptor-positive breas...

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Bibliographic Details
Main Authors: Nathalie Ferrand, Anne Gnanapragasam, Guillaume Dorothee, Gérard Redeuilh, Annette K Larsen, Michèle Sabbah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3912128?pdf=render

Internet

http://europepmc.org/articles/PMC3912128?pdf=render

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