Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature

We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient pres...

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Main Authors: Kevin Zarrabi, Ved Desai, Brandom Yim, Theodore G. Gabig
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2016/5612749
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spelling doaj-d2adfc7cc51b40c780e630fbae954fca2020-11-24T22:24:32ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/56127495612749Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the LiteratureKevin Zarrabi0Ved Desai1Brandom Yim2Theodore G. Gabig3Department of Medicine, Stony Brook University School of Medicine, Stony Brook, NY, USADepartment of Medicine, Stony Brook University School of Medicine, Stony Brook, NY, USADepartment of Medicine, Stony Brook University School of Medicine, Stony Brook, NY, USADepartment of Medicine, Stony Brook University School of Medicine, Stony Brook, NY, USAWe report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities.http://dx.doi.org/10.1155/2016/5612749
collection DOAJ
language English
format Article
sources DOAJ
author Kevin Zarrabi
Ved Desai
Brandom Yim
Theodore G. Gabig
spellingShingle Kevin Zarrabi
Ved Desai
Brandom Yim
Theodore G. Gabig
Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature
Case Reports in Hematology
author_facet Kevin Zarrabi
Ved Desai
Brandom Yim
Theodore G. Gabig
author_sort Kevin Zarrabi
title Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature
title_short Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature
title_full Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature
title_fullStr Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature
title_full_unstemmed Primary Diffuse Large B-Cell Lymphoma Localized to the Lacrimal Sac: A Case Presentation and Review of the Literature
title_sort primary diffuse large b-cell lymphoma localized to the lacrimal sac: a case presentation and review of the literature
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2016-01-01
description We report a rare case of diffuse large B-cell lymphoma (DLBCL) of the lacrimal sac in a 50-year-old male. The incidence of primary ocular lymphoma is low and it is considered a rare disease. Moreover, reports of ocular DLBCL are uncommon and the disease remains poorly characterized. Our patient presented for management of osteomyelitis and was incidentally found to have a painless swelling and cyst around his right eye. A PET/CT scan revealed hypermetabolic activity within the lacrimal sac and a subsequent excisional biopsy of the mass yielded histopathology consistent with DLBCL. Consequently, the patient underwent treatment with R-CHOP therapy. The patient responded well to chemotherapy with a substantial shrinkage in tumor burden and the disease remained localized. Herein, we present a rare case of primary ocular lymphoma, highlight the importance of early diagnosis, and review current treatment modalities.
url http://dx.doi.org/10.1155/2016/5612749
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