USE OF EXTEMPORANEOUS MAGISTRAL PREPARATIONS IN PEDIATRIC PATIENTS OF A PUBLIC HOSPITAL

• Main Authors: Josneri Flores Britto, Gladistone Correia Messias, Érika Pereira De Souza, Tamara Temóteo De Araújo, Nília Maria de Brito Lima Prado
• Format: Article
• Language: Portuguese
• Published: Universidade Estadual do Sudoeste da Bahia 2017-05-01
• Series: Revista Saúde.com
• Subjects: Off-Label Use; Inappropriate prescribing; pediatrics; Pharmaceutical preparations
• Online Access: http://www.uesb.br/revista/rsc/ojs/index.php/rsc/article/view/374/412

This is a descriptive study of retrospective evaluating medical prescriptions containing extemporaneous compounding formulations of a maternal and child public hospital from June 2011 to June 2012. We analyzed 82 prescriptions containing extemporaneous compounding preparations involving 19 therapeutic classes. The results indicated that (64.6%) prescriptions presented use restriction considering the age. Sildenafil and caffeine were the most used formulations with inappropriate doses and restricted use by age group. In addition, in no prescription have been described the excipients recommended for masterful preparation. The most prevalent diagnosis was prematurity (45.1%) and preterm infants less than 37 weeks (54.9%) were those who used more preparations that are extemporaneous in the Intensive Care Unit (ICU). It concluded that health professionals should be aware of the risks of the use of extemporaneous preparations for children in hospitals, given that some drugs are inappropriate, untested or presentations not suitable for children and with great possibility of causing Adverse Drug Reactions (ADR).