Importance of immune status for prognosis chronic borreliosis infections

• Main Authors: N. S. Minoranskaya, A. N. Uskov, P. V. Sarap
• Format: Article
• Language: Russian
• Published: Journal Infectology 2014-09-01
• Series: Žurnal Infektologii
• Subjects: chronic ixodes tick-borne borreliosis; prognosis; immune status; cytokines
• Online Access: https://journal.niidi.ru/jofin/article/view/218

Tendency to chronization of infectious process is characteristic of a current the Ixodes tick-borne borreliosis. Early identification of laboratory signs of risk of development of a chronic process of disease will allow to correct in due time therapy and to prevent a disease failure.Research objective: search of criteria for chronization in the retrospective analysis of the immune status of patients with various clinical forms of sharp ixodes tick-borne borreliosis.Materials and methods: clinical trials are executed at 161 patients with a chronic current and 420 patients with a sharp process of disease. Results of the retrospective analysis of the immune status and cytokines taking into account recovery and disease chronization are given.Results of research: predictive criteria of chronization of an erythema form of Ixodes tick-borne borreliosis were decrease in absolute quantity of lymphocytes, a phagocytic index, number of the phagocytic neutrophils, the raised level of the total IgM. Significant criteria of chronization of an illness after the ended non-erythema’s form of a disease were decrease in an expression of cytotoxic CD8+ of cells, decrease CD4+/CD8+ of cells and decrease in number the phagocytic neutrophils. For all clinical forms of a sharp process of Ixodes tick-borne borreliosis the increased synthesis interleukin-8 during the convalescence period at patients with the subsequent chronization of a disease was characteristic. Preservation of high level of interleukin-1β secretion and a neoplasm necrosis factor-α after the ended non-erythema’s form of an illness was predictive criterion of chronization of a disease. Characteristic of production cytokines at patients with the combined course of a borreliosis-encephalitis infection in the sharp period of a disease was high level of synthesis interleukin-4.Conclusion: adverse predictive criteria of development of a chronic process of Ixodes tick-borne borreliosis are failure of a phagocytic link to immune system, decrease in an expression of cytotoxic CD8+ of the cells, the increased synthesis interleukin-8 and interleukin-4.