Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease

Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease

Huntington's disease (HD) is a fatal, inherited neurodegenerative CAG disorder characterized by marked brain atrophy. We used magnetic resonance imaging (MRI) with manual volumetry for three dimensional (3D) morphological phenotyping of ex vivo brains of R6/2 mice, the most commonly used model...

Full description

Bibliographic Details
Main Authors:	S.J. Sawiak, N.I. Wood, G.B. Williams, A.J. Morton, T.A. Carpenter
Format:	Article
Language:	English
Published:	Elsevier 2009-01-01
Series:	Neurobiology of Disease
Subjects:	Magnetic resonance imaging R6/2 mice Manual volumetry Neurodegeneration
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996108002143

Similar Items

Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry
by: S.J. Sawiak, et al.
Published: (2009-01-01)

Hippocampal volumetry: Normative data in the Indian population
by: Aravind Narayan Mohandas, et al.
Published: (2014-01-01)

Correlation between voxel based morphometry and manual volumetry in magnetic resonance images of the human brain
by: Ricardo R. Uchida, et al.
Published: (2008-03-01)

Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease
by: Simone Rolfes, et al.
Published: (2020-10-01)

The importance of accurate anatomic assessment for the volumetric analysis of the amygdala
by: L. Bonilha, et al.
Published: (2005-03-01)

Comparison of Manual Cross-Sectional Measurements and Automatic Volumetry of the Corpus Callosum, and Their Clinical Impact: A Study on Type 1 Diabetes and Healthy Controls
by: Tor-björn Claesson, et al.
Published: (2020-01-01)

Volume and asymmetry abnormalities of insula in antipsychotic-naive schizophrenia: A 3-Tesla magnetic resonance imaging study
by: Harve Shanmugam Virupaksha, et al.
Published: (2012-01-01)

Magnetic resonance imaging (MRI) volumetry in children with nonlesional epilepsy, does it help?
by: Ehab Ali Abdelgawad, et al.
Published: (2021-01-01)

Objective quantification of emphysema: Determining best threshold on MDCT 3D volumetry; based on lung function evaluation
by: Nasef Abdelsalam Rezk, et al.
Published: (2014-04-01)

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models
by: Rona K. Graham, et al.
Published: (2006-02-01)

“Ectopic” theta oscillations and interictal activity during slow-wave state in the R6/1 mouse model of Huntington's disease
by: Michele Pignatelli, et al.
Published: (2012-12-01)

Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy.
by: Stephen J Sawiak, et al.
Published: (2012-01-01)

Brain volumetrics, regional cortical thickness and radiographic findings in children with cyanotic congenital heart disease using quantitative magnetic resonance imaging
by: Alsiagy A. Salama, M.D., et al.
Published: (2016-12-01)

The Evaluation of the Brain Alterations in Epileptic Patients Using Structural Magnetic Resonance Imaging
by: Hanieh Mobarak Salari, et al.
Published: (2019-09-01)

Reduced striatal volumes in Parkinson’s disease: a magnetic resonance imaging study
by: Pitcher Toni L, et al.
Published: (2012-08-01)

Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease
by: A. Di Pardo, et al.
Published: (2020-09-01)

Association between improvement of clinical signs and decrease of ventricular volume after ventriculoperitoneal shunting in dogs with internal hydrocephalus
by: Martin J. Schmidt, et al.
Published: (2019-05-01)

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
by: Jeremy M. Van Raamsdonk, et al.
Published: (2007-04-01)

EXPERIENCE OF THE CULONOMETRIC ESTIMATION OF THE CORROSION-ACTIVE SURFACE OF AUSTENITIC STEEL IN AN AGGRESSIVE ELECTROLYTE AT CONVERTIBLE DEFORMATION
by: Kuzmak Alexander E., et al.
Published: (2019-06-01)

Normal right and left ventricular volumes prospectively obtained from cardiovascular magnetic resonance in awake, healthy, 0- 12 year old children
by: Laura J. Olivieri, et al.
Published: (2020-02-01)

Progesterone Neuroprotection in the Wobbler Mouse, a Genetic Model of Spinal Cord Motor Neuron Disease
by: Marı́a Claudia Gonzalez Deniselle, et al.
Published: (2002-12-01)

Molecular Biology of Huntington’s Disease
by: Nagehan Ersoy, et al.
Published: (2005-02-01)

The Role of Microglia and Astrocytes in Huntington’s Disease
by: Thulani H. Palpagama, et al.
Published: (2019-10-01)

Altered selenium status in Huntington's disease: Neuroprotection by selenite in the N171-82Q mouse model
by: Zhen Lu, et al.
Published: (2014-11-01)

Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis
by: Xuedan Feng, et al.
Published: (2017-05-01)

Etude des propriétés d'adsorption d'hydrocarbures de composés organométalliques poreux flexibles
by: Khuong Trung, Thuy
Published: (2011)

Ataxic Symptoms in Huntington’s Disease Transgenic Mouse Model Are Alleviated by Chlorzoxazone
by: Polina A. Egorova, et al.
Published: (2020-04-01)

Correlation between hippocampal volumes and proton magnetic resonance spectroscopy of the posterior cingulate gyrus and hippocampi in Alzheimer's disease
by: Eun Joo Park, et al.

Prevalence of seizures in dogs and cats with idiopathic internal hydrocephalus and seizure prevalence after implantation of a ventriculo‐peritoneal shunt
by: Daniela Farke, et al.
Published: (2020-09-01)

Basal forebrain atrophy in frontotemporal dementia
by: Rhian S. Convery, et al.
Published: (2020-01-01)

Evaluation of early changes of cartilage biomarkers following arthroscopic meniscectomy in young Egyptian adults
by: Hamdy Khamis Koryem, et al.
Published: (2015-09-01)

Semi-automated computed tomography Volumetry can predict hemihepatectomy specimens’ volumes in patients with hepatic malignancy
by: Philipp Mayer, et al.
Published: (2019-02-01)

Amygdala subnuclei are differentially affected in the different genetic and pathological forms of frontotemporal dementia
by: Martina Bocchetta, et al.
Published: (2019-12-01)

Evaluation of a 3‐dimensional ultrasound device for noninvasive measurement of urinary bladder volume in dogs
by: Matthew R. DiFazio, et al.
Published: (2020-07-01)

The importance of blood flow volume in the brainsupplying arteries for the clinical management – the impact of collateral circulation
by: Michał Elwertowski, et al.
Published: (2018-06-01)

MR Volumetry of Lung Nodules: A Pilot Study
by: Jean Delacoste, et al.
Published: (2019-02-01)

Biometric features of the capybara´s body and small intestine Hydrochoerus hydrochaeris Linnaeus, 1766 (Mammalia, Rodentia, Hydrochaeridae)
by: Tarcízio Antônio Rego de Paula, et al.
Published: (2006-09-01)

Modelagem do volume de reservatórios de irrigação para fins de outorga e planejamento agrícola Modeling of the irrigation reservoirs for concession and agricultural projection
by: Adroaldo Dias Robaina, et al.
Published: (2009-12-01)

CT Volumetry of Convoluted Objects—A Simple Method Using Volume Averaging
by: Rani Al-Senan, et al.
Published: (2021-04-01)

Etude IRM du vieillissement articulaire à 1.5 et 7 Teslas : Approches volumiques et cartographiques
by: Goebel, Jean-Christophe
Published: (2009)