Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

The endoplasmic reticulum (ER) is an important site for protein folding and maturation in eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its folding capacity. However, the physiological demands or aberrations in folding may result in an imbalance which can le...

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Bibliographic Details
Main Authors: Christopher J. Adams, Megan C. Kopp, Natacha Larburu, Piotr R. Nowak, Maruf M. U. Ali
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
unfolded protein response (UPR)
IRE1 inositol-requiring enzyme 1
ER stress
crystal structures
Hsp70
BiP
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00011/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00011/full

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