Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice

Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice

Hemophagocytic lymphohistiocytosis (HLH) has recently been increasingly reported as an important complication after stem cell transplantation, in line with the increase in the number of HLA-mismatched transplantation. Although previous clinical studies have shown an elevation of inflammatory cytokin...

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Bibliographic Details
Main Authors: Satoshi Yoshihara, Yuying Li, Jinxing Xia, Nichole Danzl, Megan Sykes, Yong-Guang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
allogeneic SCT
hypercytokinemia
inflammation
immune activation
hemophagocytic lymphohistiocytosis (HLH)
graft-vs.-host disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00186/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00186/full

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