Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.

Bibliographic Details
Main Authors: Sergio Valbuena, Álvaro García, Wilfrid Mazier, Ana V. Paternain, Juan Lerma
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13004-9
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spelling doaj-d263a07d71f248b588f195680de08d052021-05-11T12:13:18ZengNature Publishing GroupNature Communications2041-17232019-11-0110111210.1038/s41467-019-13004-9Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome modelSergio Valbuena0Álvaro García1Wilfrid Mazier2Ana V. Paternain3Juan Lerma4Instituto de Neurociencias CSIC-UMHInstituto de Neurociencias CSIC-UMHInstituto de Neurociencias CSIC-UMHInstituto de Neurociencias CSIC-UMHInstituto de Neurociencias CSIC-UMHExaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.https://doi.org/10.1038/s41467-019-13004-9
collection DOAJ
language English
format Article
sources DOAJ
author Sergio Valbuena
Álvaro García
Wilfrid Mazier
Ana V. Paternain
Juan Lerma
spellingShingle Sergio Valbuena
Álvaro García
Wilfrid Mazier
Ana V. Paternain
Juan Lerma
Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
Nature Communications
author_facet Sergio Valbuena
Álvaro García
Wilfrid Mazier
Ana V. Paternain
Juan Lerma
author_sort Sergio Valbuena
title Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_short Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_full Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_fullStr Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_full_unstemmed Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model
title_sort unbalanced dendritic inhibition of ca1 neurons drives spatial-memory deficits in the ts2cje down syndrome model
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.
url https://doi.org/10.1038/s41467-019-13004-9
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