Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning
High-quality gRNA activity data is needed for accurate on-target efficiency predictions. Here the authors generate activity data for over 10,000 gRNA and build a deep learning model CRISPRon for improved performance predictions.
Bibliographic Details
| Main Authors: |
Xi Xiang,
Giulia I. Corsi,
Christian Anthon,
Kunli Qu,
Xiaoguang Pan,
Xue Liang,
Peng Han,
Zhanying Dong,
Lijun Liu,
Jiayan Zhong,
Tao Ma,
Jinbao Wang,
Xiuqing Zhang,
Hui Jiang,
Fengping Xu,
Xin Liu,
Xun Xu,
Jian Wang,
Huanming Yang,
Lars Bolund,
George M. Church,
Lin Lin,
Jan Gorodkin,
Yonglun Luo |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23576-0
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