Grifolic acid induces GH3 adenoma cell death by inhibiting ATP production through a GPR120-independent mechanism

Grifolic acid induces GH3 adenoma cell death by inhibiting ATP production through a GPR120-independent mechanism

Abstract Background Grifolic acid is a derivative of grifolin, an antitumor natural compound, and it was reported as an agonist of free fatty acid receptor GPR120. Little is known about its antitumor effects and the involvement of GPR120. Methods GH3 cells, the rat anterior pituitary adenoma cells,...

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Bibliographic Details
Main Authors: Yufeng Zhao, Lei Zhang, Aili Yan, Di Chen, Rong Xie, Yingguang Liu, Xiangyan Liang, Yanyan Zhao, Lanlan Wei, Jun Yu, Xi Xu, Xingli Su
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Grifolic acid
GH3 cells
Mitochondria
Cell death
Online Access:http://link.springer.com/article/10.1186/s40360-018-0215-4

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