Invariant NKT Cell Lines Derived from the NOD·H2h4 Mouse Enhance Autoimmune Thyroiditis

To study the role of invariant Natural Killer T cell (iNKT) cells in autoimmune thyroiditis, we derived two iNKT cell lines from the spleens of NOD·H2h4 mice, a strain that develops spontaneous autoimmune thyroiditis exacerbated by excess dietary iodine. The two lines were CD1d-restricted and expr...

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Bibliographic Details
Main Authors: Rajni B. Sharma, Xiaoguang Fan, Patrizio Caturegli, Noel R. Rose, C. Lynne Burek
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Thyroid Research
Online Access:http://dx.doi.org/10.4061/2011/895923