Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

ABSTRACT A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) betwe...

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Bibliographic Details
Main Authors: Diego H. Cáceres, Alejandra Zuluaga, Ángela M. Tabares, Tom Chiller, Ángel González, Beatriz L. Gómez
Format: Article
Language:English
Published: Universidade de São Paulo 2017-12-01
Series:Revista do Instituto de Medicina Tropical de São Paulo
Subjects:
Cryptococcosis
Cryptococcus
Antigen
Diagnosis
Point-of-care
Lateral Flow Assay
Immunochromatographic assay
Latex agglutination system
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652017005000507&lng=en&tlng=en
Description
Summary:ABSTRACT A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.
ISSN:1678-9946

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