A Study on Acetylglutamine Pharmacokinetics in Rat Blood and Brain Based on Liquid Chromatography-Tandem Mass Spectrometry and Microdialysis Technique

A Study on Acetylglutamine Pharmacokinetics in Rat Blood and Brain Based on Liquid Chromatography-Tandem Mass Spectrometry and Microdialysis Technique

Acetylglutamine (NAG) is the derivative of glutamine, which is the richest free amino acid in the human body. In this work, a novel reliable method of the combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and microdialysis (MD) technique for the evaluation of NAG and its metab...

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Bibliographic Details
Main Authors:	Shouchao Xu, Chang Li, Huifen Zhou, Li Yu, Ling Deng, Jiazhen Zhu, Haitong Wan, Yu He
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-04-01
Series:	Frontiers in Pharmacology
Subjects:	liquid chromatography-tandem mass spectrometry acetylglutamine glutamic acid γ-aminobutyric acid microdialysis blood-brain barrier
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00508/full

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