Hydrophobic Mycobacterial Antigens Elicit Polyfunctional T Cells in Mycobacterium bovis Immunized Cattle: Association With Protection Against Challenge?

Hydrophobic Mycobacterial Antigens Elicit Polyfunctional T Cells in Mycobacterium bovis Immunized Cattle: Association With Protection Against Challenge?

Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a chronic disease of cattle with a detrimental impact on food quality and production. Research on bTB vaccines has predominantly been focused on proteinaceous antigens. However, mycobacteria have a thick and intricate lipid outer layer and...

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Bibliographic Details
Main Authors: Lindert Benedictus, Sabine Steinbach, Thomas Holder, Douwe Bakker, Christina Vrettou, W. Ivan Morrison, Martin Vordermeier, Timothy Connelley
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
bovine tuberculosis
lipopeptides
Mycobacterium bovis
vaccine
hydrophobic antigens
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588180/full

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