Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region.

Multiple approaches are being utilized to develop therapeutics to treat HIV infection. One approach is designed to inhibit entry of HIV into host cells, with a target being the viral envelope glycoprotein, gp120. Polyanionic compounds have been shown to be effective in inhibiting HIV entry, with a m...

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Bibliographic Details
Main Authors: Louis R Hollingsworth, Anne M Brown, Richard D Gandour, David R Bevan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5773097?pdf=render