The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells

The paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplifica...

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Main Authors:	D. A. Karseladze, I. V. Poddubnaya, A. I. Karseladze
Format:	Article
Language:	Russian
Published:	ABV-press 2014-08-01
Series:	Opuholi Ženskoj Reproduktivnoj Sistemy
Subjects:	triple-negative breast cancer topoisomerase iiα epidermal growth factor receptor aneusomy of chromosomes 7 and 17
Online Access:	https://ojrs.abvpress.ru/ojrs/article/view/266

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spelling	doaj-d226a0ab29b949969f7a5c70b70142362021-07-29T08:46:49ZrusABV-pressOpuholi Ženskoj Reproduktivnoj Sistemy1994-40981999-86272014-08-0104333910.17650/1994-4098-2010-0-4-33-39282The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cellsD. A. Karseladze0I. V. Poddubnaya1A. I. Karseladze2N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical SciencesDepartment of Oncology, Russian Medical Academy of Postgraduate Education, Russian Agency for Health CareDepartment for Pathological Anatomy of Human Tumors, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowThe paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplification usually occurs in the tumors responsive to chemotherapy including anthracycline drugs. The altered status of the above genes should be interpreted in the context of aneusomy of chromosomes 7 and 17, on which they are located. No association was found between the pattern of EGFR and TOP IIα gene abnormalities and the basaloid phenotype of BC.https://ojrs.abvpress.ru/ojrs/article/view/266triple-negative breast cancertopoisomerase iiαepidermal growth factor receptoraneusomy of chromosomes 7 and 17
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	D. A. Karseladze I. V. Poddubnaya A. I. Karseladze
spellingShingle	D. A. Karseladze I. V. Poddubnaya A. I. Karseladze The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells Opuholi Ženskoj Reproduktivnoj Sistemy triple-negative breast cancer topoisomerase iiα epidermal growth factor receptor aneusomy of chromosomes 7 and 17
author_facet	D. A. Karseladze I. V. Poddubnaya A. I. Karseladze
author_sort	D. A. Karseladze
title	The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
title_short	The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
title_full	The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
title_fullStr	The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
title_full_unstemmed	The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells
title_sort	status of epidermal growth factor receptor and topoisomerase iiα genes in triple-negative breast cancer cells
publisher	ABV-press
series	Opuholi Ženskoj Reproduktivnoj Sistemy
issn	1994-4098 1999-8627
publishDate	2014-08-01
description	The paper gives the results of studying the genes of epidermal growth factor receptor (EGFR) and topoisomerase IIα (TOP IIα) in patients with triple-negative breast cancer (BC). It is suggested that the lack of EGFR gene amplification might serve as a factor of good prognosis. TOP IIα gene amplification usually occurs in the tumors responsive to chemotherapy including anthracycline drugs. The altered status of the above genes should be interpreted in the context of aneusomy of chromosomes 7 and 17, on which they are located. No association was found between the pattern of EGFR and TOP IIα gene abnormalities and the basaloid phenotype of BC.
topic	triple-negative breast cancer topoisomerase iiα epidermal growth factor receptor aneusomy of chromosomes 7 and 17
url	https://ojrs.abvpress.ru/ojrs/article/view/266
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The status of epidermal growth factor receptor and topoisomerase IIα genes in triple-negative breast cancer cells

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