Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy

Dynamic changes in the mouse skeletal muscle proteome during denervation-induced atrophy

Loss of neuronal stimulation enhances protein breakdown and reduces protein synthesis, causing rapid loss of muscle mass. To elucidate the pathophysiological adaptations that occur in atrophying muscles, we used stable isotope labelling and mass spectrometry to quantify protein expression changes ac...

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Bibliographic Details
Main Authors: Franziska Lang, Sriram Aravamudhan, Hendrik Nolte, Clara Türk, Soraya Hölper, Stefan Müller, Stefan Günther, Bert Blaauw, Thomas Braun, Marcus Krüger
Format: Article
Language:English
Published: The Company of Biologists 2017-07-01
Series:Disease Models & Mechanisms
Subjects:
Muscle atrophy
Denervation
Pulsed SILAC
Ubiquitination
Random forest
Online Access:http://dmm.biologists.org/content/10/7/881

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