Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

Progress toward overcoming hypoxia-induced resistance to solid tumor therapy

Sergey V Karakashev, Mauricio J Reginato Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer...

Full description

Bibliographic Details
Main Authors: Karakashev SV, Reginato MJ
Format: Article
Language:English
Published: Dove Medical Press 2015-08-01
Series:Cancer Management and Research
Online Access:http://www.dovepress.com/progress-toward-overcoming-hypoxia-induced-resistance-to-solid-tumor-t-peer-reviewed-article-CMAR
id doaj-d21055a71c2e42188ca6838fc7935443
record_format Article
spelling doaj-d21055a71c2e42188ca6838fc79354432020-11-24T23:05:07ZengDove Medical PressCancer Management and Research1179-13222015-08-012015default25326423118Progress toward overcoming hypoxia-induced resistance to solid tumor therapyKarakashev SVReginato MJSergey V Karakashev, Mauricio J Reginato Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance. Keywords: HIF-1, cancer, chemoresistance, signaling, apoptosishttp://www.dovepress.com/progress-toward-overcoming-hypoxia-induced-resistance-to-solid-tumor-t-peer-reviewed-article-CMAR
collection DOAJ
language English
format Article
sources DOAJ
author Karakashev SV
Reginato MJ
spellingShingle Karakashev SV
Reginato MJ
Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
Cancer Management and Research
author_facet Karakashev SV
Reginato MJ
author_sort Karakashev SV
title Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
title_short Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
title_full Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
title_fullStr Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
title_full_unstemmed Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
title_sort progress toward overcoming hypoxia-induced resistance to solid tumor therapy
publisher Dove Medical Press
series Cancer Management and Research
issn 1179-1322
publishDate 2015-08-01
description Sergey V Karakashev, Mauricio J Reginato Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance. Keywords: HIF-1, cancer, chemoresistance, signaling, apoptosis
url http://www.dovepress.com/progress-toward-overcoming-hypoxia-induced-resistance-to-solid-tumor-t-peer-reviewed-article-CMAR
work_keys_str_mv AT karakashevsv progresstowardovercominghypoxiainducedresistancetosolidtumortherapy
AT reginatomj progresstowardovercominghypoxiainducedresistancetosolidtumortherapy
_version_ 1725627484799500288

Similar Items