Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist

Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist

Positron emission tomography (PET) provides useful information in target engagement or receptor occupancy in the brain for central nervous system (CNS) drug development, however, dose selection for human PET studies is challenging and largely empirical. Here, we describe a translational pharmacokine...

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Bibliographic Details
Main Authors: Yan Xu, Xin Miao, Paulien Ravenstijn, Anja Hijzen, Mark E. Schmidt, Partha Nandy, Honghui Zhou
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.12711

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