MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging

MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging

MALT1 plays an important role in innate and adaptive immune signaling by acting as a scaffold protein that mediates NF-κB signaling. In addition, MALT1 is a cysteine protease that further fine tunes proinflammatory signaling by cleaving specific substrates. Deregulated MALT1 activity has been associ...

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Bibliographic Details
Main Authors: Annelies Demeyer, Elien Van Nuffel, Griet Baudelet, Yasmine Driege, Marja Kreike, David Muyllaert, Jens Staal, Rudi Beyaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
atopic dermatitis
skin inflammation
MALT1
lymphocytes
Tregs
Th2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02330/full

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