Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection

Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection

T cell dysfunction and immunosuppression are characteristic for chronic viral infections and contribute to viral persistence. Overcoming these burdens is the goal of new therapeutic strategies to cure chronic infectious diseases. We recently described that therapeutic vaccination of chronic retrovir...

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Bibliographic Details
Main Authors: Torben Knuschke, Olga Rotan, Wibke Bayer, Sebastian Kollenda, Julia Dickow, Kathrin Sutter, Wiebke Hansen, Ulf Dittmer, Karl S. Lang, Matthias Epple, Jan Buer, Astrid M. Westendorf
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
nanoparticles
therapeutic vaccine
chronic retrovirus infection
T cell immunity
type I interferons
interferon alpha
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00614/full

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