First case of AML with rare chromosome translocations: a case report of twins

• Main Authors: Lin Wang, Yanhua Sun, Yanli Sun, Lingbin Meng, Xin Xu
• Format: Article
• Language: English
• Published: BMC 2018-04-01
• Series: BMC Cancer
• Subjects: AML; Genetic rearrangement; FLT3/ITD; WGS
• Online Access: http://link.springer.com/article/10.1186/s12885-018-4396-4

Abstract Background Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized. Case presentation Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient’s healthy sibling as a sequencing control. Conclusion This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15.