First case of AML with rare chromosome translocations: a case report of twins

Abstract Background Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contra...

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Bibliographic Details
Main Authors: Lin Wang, Yanhua Sun, Yanli Sun, Lingbin Meng, Xin Xu
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cancer
Subjects:
AML
WGS
Online Access:http://link.springer.com/article/10.1186/s12885-018-4396-4
Description
Summary:Abstract Background Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized. Case presentation Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient’s healthy sibling as a sequencing control. Conclusion This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15.
ISSN:1471-2407