Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment

Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment

We report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12S mutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was...

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Main Authors: Leelawadee Sriboonnark, Harleen Arora, Leyre Falto-Aizpurua, Sonal Choudhary, Elizabeth Alvarez Connelly
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2015/934865
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spelling doaj-d1ffbd822f004bb08f106392c7ec815b2020-11-25T01:08:16ZengHindawi LimitedCase Reports in Pediatrics2090-68032090-68112015-01-01201510.1155/2015/934865934865Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin TreatmentLeelawadee Sriboonnark0Harleen Arora1Leyre Falto-Aizpurua2Sonal Choudhary3Elizabeth Alvarez Connelly4Division of Dermatology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandMiller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USAMiller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USAMiller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USAMiller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USAWe report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12S mutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was observed. Interestingly, an unexpected significant improvement of acanthosis nigricans on her neck and dorsum of her hands was found as well. We present this case as a successful treatment option by using oral isotretinoin for the treatment of acanthosis nigricans in Costello syndrome patients.http://dx.doi.org/10.1155/2015/934865
collection DOAJ
language English
format Article
sources DOAJ
author Leelawadee Sriboonnark
Harleen Arora
Leyre Falto-Aizpurua
Sonal Choudhary
Elizabeth Alvarez Connelly
spellingShingle Leelawadee Sriboonnark
Harleen Arora
Leyre Falto-Aizpurua
Sonal Choudhary
Elizabeth Alvarez Connelly
Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
Case Reports in Pediatrics
author_facet Leelawadee Sriboonnark
Harleen Arora
Leyre Falto-Aizpurua
Sonal Choudhary
Elizabeth Alvarez Connelly
author_sort Leelawadee Sriboonnark
title Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
title_short Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
title_full Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
title_fullStr Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
title_full_unstemmed Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment
title_sort costello syndrome with severe nodulocystic acne: unexpected significant improvement of acanthosis nigricans after oral isotretinoin treatment
publisher Hindawi Limited
series Case Reports in Pediatrics
issn 2090-6803
2090-6811
publishDate 2015-01-01
description We report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12S mutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was observed. Interestingly, an unexpected significant improvement of acanthosis nigricans on her neck and dorsum of her hands was found as well. We present this case as a successful treatment option by using oral isotretinoin for the treatment of acanthosis nigricans in Costello syndrome patients.
url http://dx.doi.org/10.1155/2015/934865
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AT harleenarora costellosyndromewithseverenodulocysticacneunexpectedsignificantimprovementofacanthosisnigricansafteroralisotretinointreatment
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