The effects of PPAR-γ agonist pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor, memory impairment, and oxidative stress status in lipopolysaccharide-treated rats

Objective(s): The aim of current study was to evaluate improving effects of pioglitazone as an agonist of peroxisome proliferator-activated receptor gamma (PPARγ), on brain-derived neurotrophic factor (BDNF) and cytokines as well as tissue oxidative damage criteria in the hippocampus in a rat model...

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Bibliographic Details
Main Authors: Farimah Beheshti, Mahmoud Hosseini, Milad Hashemzehi, Mohammad Soukhtanloo, Majid Khazaei, Mohammad Naser Shafei
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:http://ijbms.mums.ac.ir/article_13239_15099cf96759ffb0a4e9c0ea7e6400f5.pdf