Effectiveness of theobromine on inhibition of 1,2-dimethylhydrazine-induced rat colon cancer by suppression of the Akt/GSK3β/β-catenin signaling pathway

This study aimed to investigate the effect of theobromine on dimethylhydrazine (DMH)-induced colon cancer. Male Wistar rats were divided into four groups and injected with saline (negative control) or 30 mg/kg DMH (other three groups) two times a week for 12 weeks. The negative control and DMH-treat...

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Bibliographic Details
Main Authors: Sara Shojaei-Zarghani, Maryam Rafraf, Ahmad Yari Khosroushahi, Shirin Sheikh-Najafi
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Functional Foods
Subjects:
Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S175646462030517X