Inhibition of autophagy aggravates molybdenum-induced mitochondrial dysfunction by aggravating oxidative stress in duck renal tubular epithelial cells

Inhibition of autophagy aggravates molybdenum-induced mitochondrial dysfunction by aggravating oxidative stress in duck renal tubular epithelial cells

Excessive molybdenum (Mo) has adverse effects on animals. To elucidate the effects of autophagy on Mo-induced nephrotoxicity, the duck renal tubular epithelial cells were cultured in medium in absence and presence of (NH4)6Mo7O24.4H2O (0, 480, 720, 960 μM Mo), 3-Methyladenine (3-MA) (2.5 μM), and th...

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Bibliographic Details
Main Authors: Jionghan Zhuang, Gaohui Nie, Ruiming Hu, Chang Wang, Chenghong Xing, Guyue Li, Guoliang Hu, Fan Yang, Caiying Zhang
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Molybdenum
Autophagy
Oxidative stress
Mitochondrion
Renal tubular epithelial cell
Duck
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320316079

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