Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study

Approaches to identify genetic variants that influence the risk for onset of fragile X-associated primary ovarian insufficiency (FXPOI): a preliminary study

Fragile X-associated primary ovarian insufficiency (FXPOI) is due to an X-linked mutation that results from the expansion of a CGG repeat sequence located in the 5' untranslated region of the FMR1 gene (premutation, PM). About 20% of women who carry the PM have cessation of menses before age 40...

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Bibliographic Details
Main Authors: Emily G. Allen, Wendy E. Grus, Sarayu eNarayan, Whitney eEspinel, Stephanie L. Sherman
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Genetics
Subjects:
Menopause
Primary Ovarian Insufficiency
Epistasis
disorder
Repeat expansion
ovarian failure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00260/full

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