Mechanism of action of cocoa on bone metabolism in calcium- and estrogen-deficient rat model of osteoporosis: Evidence for site and dose-related responses and involvement of IGF-I

Mechanism of action of cocoa on bone metabolism in calcium- and estrogen-deficient rat model of osteoporosis: Evidence for site and dose-related responses and involvement of IGF-I

The present study evaluated the impact of cocoa on skeleton of ovariectomized rats. Animals were randomized into four groups: sham (basal diet: AIN-93M Ca and P-deficient), and three ovariectomized groups: OVX (basal diet), C6 and C12 (6% and 12% cocoa powder, respectively). Urinary calcium loss was...

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Bibliographic Details
Main Authors: Bahareh Sarmadi, Amin Ismail, Loqman Yusof, Mohd Faridz Mod Yunoh
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Journal of Functional Foods
Subjects:
Cocoa
Bone quality
Bone strength
Oxidative stress
Inflammatory biomarkers
Postmenopausal osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464620300177

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