Deep tumor imaging by upconversion nanoparticles

Deep tumor imaging by upconversion nanoparticles

In this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor. For using nanoparticles for biomedical purposes is implemented a technique for coating nanoparticles with polymers, such as PEG and PSA. This approach provides low non...

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Main Authors: Sholina Nataly, Demina Polina, Khochenkov Dmitry, Generalova Alla, Nechaev Andrey, Khaydukov Eugeny
Format: Article
Language:English
Published: EDP Sciences 2018-01-01
Series:EPJ Web of Conferences
Online Access:https://doi.org/10.1051/epjconf/201819004020
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spelling doaj-d1c8e3ca395f47c6a291976d07cf4be82021-08-02T01:13:29ZengEDP SciencesEPJ Web of Conferences2100-014X2018-01-011900402010.1051/epjconf/201819004020epjconf_hbsm2018_04020Deep tumor imaging by upconversion nanoparticlesSholina NatalyDemina Polina0Khochenkov DmitryGeneralova AllaNechaev Andrey1Khaydukov EugenyFederal Scientific Research Center Crystallography and Photonics RASInstitute of Fine Chemical Technologies, Moscow Technol. UniversityIn this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor. For using nanoparticles for biomedical purposes is implemented a technique for coating nanoparticles with polymers, such as PEG and PSA. This approach provides low non-specific adsorption, which prolongs the circulation of UCNPs in mouse bearing Lewis Lung Cancer (LLC) up to 10 hours. These properties allow nanoparticles to quickly accumulate in the tumor. Effective delivery of particles with different polymer coatings in the tumor is demonstrated with the help of an epiluminescent imaging system.https://doi.org/10.1051/epjconf/201819004020
collection DOAJ
language English
format Article
sources DOAJ
author Sholina Nataly
Demina Polina
Khochenkov Dmitry
Generalova Alla
Nechaev Andrey
Khaydukov Eugeny
spellingShingle Sholina Nataly
Demina Polina
Khochenkov Dmitry
Generalova Alla
Nechaev Andrey
Khaydukov Eugeny
Deep tumor imaging by upconversion nanoparticles
EPJ Web of Conferences
author_facet Sholina Nataly
Demina Polina
Khochenkov Dmitry
Generalova Alla
Nechaev Andrey
Khaydukov Eugeny
author_sort Sholina Nataly
title Deep tumor imaging by upconversion nanoparticles
title_short Deep tumor imaging by upconversion nanoparticles
title_full Deep tumor imaging by upconversion nanoparticles
title_fullStr Deep tumor imaging by upconversion nanoparticles
title_full_unstemmed Deep tumor imaging by upconversion nanoparticles
title_sort deep tumor imaging by upconversion nanoparticles
publisher EDP Sciences
series EPJ Web of Conferences
issn 2100-014X
publishDate 2018-01-01
description In this work are shown the prospects of using upconversion nanoparticles (UCNPs) as markers for contrast optical imaging of a tumor. For using nanoparticles for biomedical purposes is implemented a technique for coating nanoparticles with polymers, such as PEG and PSA. This approach provides low non-specific adsorption, which prolongs the circulation of UCNPs in mouse bearing Lewis Lung Cancer (LLC) up to 10 hours. These properties allow nanoparticles to quickly accumulate in the tumor. Effective delivery of particles with different polymer coatings in the tumor is demonstrated with the help of an epiluminescent imaging system.
url https://doi.org/10.1051/epjconf/201819004020
work_keys_str_mv AT sholinanataly deeptumorimagingbyupconversionnanoparticles
AT deminapolina deeptumorimagingbyupconversionnanoparticles
AT khochenkovdmitry deeptumorimagingbyupconversionnanoparticles
AT generalovaalla deeptumorimagingbyupconversionnanoparticles
AT nechaevandrey deeptumorimagingbyupconversionnanoparticles
AT khaydukoveugeny deeptumorimagingbyupconversionnanoparticles
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