A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory...

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Main Authors:	Lea Ankri, Zoé Husson, Katarzyna Pietrajtis, Rémi Proville, Clément Léna, Yosef Yarom, Stéphane Dieudonné, Marylka Yoe Uusisaari
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-05-01
Series:	eLife
Subjects:	cerebellum cerebellar nuclei Golgi cell inhibition
Online Access:	https://elifesciences.org/articles/06262

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spelling	doaj-d1c263da458745d4b57a7b842ad9de932021-05-04T23:47:23ZengeLife Sciences Publications LtdeLife2050-084X2015-05-01410.7554/eLife.06262A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activityLea Ankri0Zoé Husson1Katarzyna Pietrajtis2Rémi Proville3https://orcid.org/0000-0002-5829-1344Clément Léna4Yosef Yarom5Stéphane Dieudonné6Marylka Yoe Uusisaari7Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelInhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceInhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceCentre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Cerebellum Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceCentre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Cerebellum Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceDepartment of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelInhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France; Institut national de la santé et de la recherche médicale, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, FranceDepartment of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, IsraelThe cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.https://elifesciences.org/articles/06262cerebellumcerebellar nucleiGolgi cellinhibition
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lea Ankri Zoé Husson Katarzyna Pietrajtis Rémi Proville Clément Léna Yosef Yarom Stéphane Dieudonné Marylka Yoe Uusisaari
spellingShingle	Lea Ankri Zoé Husson Katarzyna Pietrajtis Rémi Proville Clément Léna Yosef Yarom Stéphane Dieudonné Marylka Yoe Uusisaari A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity eLife cerebellum cerebellar nuclei Golgi cell inhibition
author_facet	Lea Ankri Zoé Husson Katarzyna Pietrajtis Rémi Proville Clément Léna Yosef Yarom Stéphane Dieudonné Marylka Yoe Uusisaari
author_sort	Lea Ankri
title	A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
title_short	A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
title_full	A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
title_fullStr	A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
title_full_unstemmed	A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity
title_sort	novel inhibitory nucleo-cortical circuit controls cerebellar golgi cell activity
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2015-05-01
description	The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.
topic	cerebellum cerebellar nuclei Golgi cell inhibition
url	https://elifesciences.org/articles/06262
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A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

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