Cognitive disorders in patients with insulin-dependent type I diabetes mellitus

• Main Authors: Parisa Jalilzadeh afshari, Ghassem Mohamadkhani, Nematollah Rouhbakhsh, Shohreh Jalaie, Ensieh Nasli Esfahani
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 2013-05-01
• Series: Audiology
• Subjects: Auditory event-related potential; amplitude; latency; type I diabetes mellitus
• Online Access: http://aud.tums.ac.ir/browse.php?a_code=A-10-1-2&slc_lang=en&sid=1

Background and Aim: Diabetes mellitus is a common disorder and causes a variety of central nervous system complications such as cognitive deficits. P300 auditory event related potential application is a well established neurophysiological approach in the assessment of cognitive performance. In this study, we compared the results of this application in patients with insulin-dependent (type I) diabetics mellitus and normal individuals.Methods: In this non-interventional study, auditory P300 was measured in oddball paradigm by using two tone burst stimuli (1000 and 2000 Hz) on 25 patients with type I diabetics mellitus with the mean age of 28.76 years and 25 age-, education- and sex-matched healthy controls with the mean age of 29.68 years. The participants were enrolled by probable and category random sampling style.Results: The mean P300 latency of the patients with type I diabetes mellitus was significantly prolonged compared with that of normal controls at all electrode sites and in both genders (p<0.001). The mean P300 amplitude of these patients was significantly lower compared with that of normal controls at all electrode sites and in both genders (p<0.001).Conclusion: Significant prolongation in P300 latency of the patients with type I diabetes mellitus shows that auditory information processing and information categorizing are slower in them. Significant reduction in P300 amplitude of the patients with type I diabetes mellitus demonstrates that working memory in these patients cannot recognize new events and update its context in accordance with them.