Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia

Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia

<p>Abstract</p> <p>We present the first <it>in vivo </it>detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and d...

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Main Authors: Dickerson Jennifer A, Raman Subha V, Al-Dahhak Roula
Format: Article
Language:English
Published: BMC 2008-04-01
Series:Journal of Cardiovascular Magnetic Resonance
Online Access:http://www.jcmr-online.com/content/10/1/15
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spelling doaj-d1b638fd2d1146aaac95670a5a8c3d302020-11-24T21:52:49ZengBMCJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2008-04-011011510.1186/1532-429X-10-15Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxiaDickerson Jennifer ARaman Subha VAl-Dahhak Roula<p>Abstract</p> <p>We present the first <it>in vivo </it>detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and dyspnea prompting referral for cardiac evaluation. These symptoms were reproduced during intravenous adenosine infusion, and simultaneous first-pass perfusion imaging showed a significant subendocardial defect; both symptoms and perfusion deficit were absent at rest. Epicardial coronaries were free of disease by invasive angiography; together, these findings support the notion of impaired myocardial perfusion reserve in FA.</p> http://www.jcmr-online.com/content/10/1/15
collection DOAJ
language English
format Article
sources DOAJ
author Dickerson Jennifer A
Raman Subha V
Al-Dahhak Roula
spellingShingle Dickerson Jennifer A
Raman Subha V
Al-Dahhak Roula
Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia
Journal of Cardiovascular Magnetic Resonance
author_facet Dickerson Jennifer A
Raman Subha V
Al-Dahhak Roula
author_sort Dickerson Jennifer A
title Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia
title_short Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia
title_full Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia
title_fullStr Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia
title_full_unstemmed Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia
title_sort myocardial ischemia in the absence of epicardial coronary artery disease in friedreich's ataxia
publisher BMC
series Journal of Cardiovascular Magnetic Resonance
issn 1097-6647
1532-429X
publishDate 2008-04-01
description <p>Abstract</p> <p>We present the first <it>in vivo </it>detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and dyspnea prompting referral for cardiac evaluation. These symptoms were reproduced during intravenous adenosine infusion, and simultaneous first-pass perfusion imaging showed a significant subendocardial defect; both symptoms and perfusion deficit were absent at rest. Epicardial coronaries were free of disease by invasive angiography; together, these findings support the notion of impaired myocardial perfusion reserve in FA.</p>
url http://www.jcmr-online.com/content/10/1/15
work_keys_str_mv AT dickersonjennifera myocardialischemiaintheabsenceofepicardialcoronaryarterydiseaseinfriedreichsataxia
AT ramansubhav myocardialischemiaintheabsenceofepicardialcoronaryarterydiseaseinfriedreichsataxia
AT aldahhakroula myocardialischemiaintheabsenceofepicardialcoronaryarterydiseaseinfriedreichsataxia
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