Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors

Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors

A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1–3. The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 with IC50 (half maximal inhibitory concentration...

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Bibliographic Details
Main Authors:	Yumei Zhou, Huaqing Cui, Xiaoming Yu, Tao Peng, Gang Wang, Xiaoxue Wen, Yunbo Sun, Shuchen Liu, Shouguo Zhang, Liming Hu, Lin Wang
Format:	Article
Language:	English
Published:	MDPI AG 2017-08-01
Series:	Molecules
Subjects:	benzofuran sulfoxide sulfone selective SIRT2 inhibitor
Online Access:	https://www.mdpi.com/1420-3049/22/8/1348

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