FAD-mutation of APP is associated with a loss of its synaptotrophic activity

FAD-mutation of APP is associated with a loss of its synaptotrophic activity

Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with extracellular accumulation of Aβ peptide that derives from the amyloid precursor protein (APP). While amyloidogenic processing of APP has received most attention, the physiological function of APP and the sequelae...

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Bibliographic Details
Main Authors: Gudrun Seeger, Ulrich Gärtner, Uwe Ueberham, Susanne Rohn, Thomas Arendt
Format: Article
Language:English
Published: Elsevier 2009-08-01
Series:Neurobiology of Disease
Subjects:
Mouse model
Alzheimer's disease
Neocortex
APP
FAD-linked mutations
Quantitative ultrastructural analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900103X

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