SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation

SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation

Abstract Background Smooth muscle cells play an important role in the development of atherosclerosis. SHP2 is known to regulate the proliferation and migration of smooth muscle cells. The purpose of this study was to determine whether the SHP2 inhibitor PHPS1 has a pro-atherosclerotic or an atheropr...

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Bibliographic Details
Main Authors: Jia Chen, Zhiyong Cao, Jingshu Guan
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Cardiovascular Disorders
Subjects:
SHP2
PHPS1
Atherosclerosis
Smooth muscle cells
Proliferation
ERK
Online Access:http://link.springer.com/article/10.1186/s12872-018-0816-2

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