Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

Abstract Background Excessive estrogen exposure is an important pathogenic factor in uterine endometrial cancer (UEC). Recent studies have reported the metabolic properties can influence the progression of UEC. However, the underlying mechanisms have not been fully elucidated. Methods Glutaminase (G...

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Bibliographic Details
Main Authors: Wen-Jie Zhou, Jie Zhang, Hui-Li Yang, Ke Wu, Feng Xie, Jiang-Nan Wu, Yan Wang, Li Yao, Yan Zhuang, Jiang-Dong Xiang, Ai-Jun Zhang, Yin-Yan He, Ming-Qing Li
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Communication and Signaling
Subjects:
Uterine endometrial cancer
CB-839
Estrogen
Autophagy
Glutamine
Online Access:http://link.springer.com/article/10.1186/s12964-019-0412-9

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