Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death

Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death

The cause of idiopathic PD is obscure, and most cases are sporadic. Oxidative stress and deficiency of various neurotrophic factors (NTFs) could be factors triggering neurodegeneration in the substantia nigra (SN). Cytoplasmic hybrid cells (cybrids) made from mitochondrial DNA of idiopathic PD subje...

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Bibliographic Details
Main Authors: Isaac G. Onyango, Jeremy B. Tuttle, James P. Bennett, Jr.
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Cybrids
Neurotrophins
Oxidative stress
Apoptosis
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000690

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